Drug Susceptibility of Mycobacterium tuberculosis Beijing Genotype and Association with MDR TB

نویسندگان

  • Jurriaan E.M. de Steenwinkel
  • Marian T. ten Kate
  • Gerjo J. de Knegt
  • Kristin Kremer
  • Rob E. Aarnoutse
  • Martin J. Boeree
  • Henri A. Verbrugh
  • Dick van Soolingen
  • Irma A.J.M. Bakker-Woudenberg
چکیده

To determine differences in the ability of Mycobacterium tuberculosis strains to withstand antituberculosis drug treatment, we compared the activity of antituberculosis drugs against susceptible Beijing and East-African/Indian genotype M. tuberculosis strains. Beijing genotype strains showed high rates of mutation within a wide range of drug concentrations, possibly explaining this genotype's association with multidrug-resistant tuberculosis.

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عنوان ژورنال:

دوره 18  شماره 

صفحات  -

تاریخ انتشار 2012